Summary
An anti-tick mRNA cocktail vaccine promotes tick detachment and prevents transmission of tick-borne an infection in guinea pigs (Sajid et al.).
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REFERENCES AND NOTES
1
J. de la Fuente, P. Kopacek, A. Lew-Tabor, C. Maritz-Olivier, Suggestions for fresh and improved vaccines against ticks and tick-borne diseases. Parasite Immunol. 38, 754–769 (2016).
2
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add advertising hereA. Sajid, J. Matias, G. Arora, C. Kurokawa, Okay. DePonte, X. Tang, G. Lynn, M.-J. Wu, U. Pal, N. Oliveres Strank, N. Pardi, S. Narasimhan, D. Weissman, E. Fikrig, mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent. Sci. Transl. Med. 13, eabj9827 (2021).
3
L. Simo, M. Kazimirova, J. Richardson, S. I. Bonnet, The significant role of tick salivary glands and saliva in tick feeding and pathogen transmission. Entrance. Cell. Infect. Microbiol. 7, 281 (2017).
4
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add advertising hereW. Trager, Extra observations on got immunity to the tick Dermacentor variabilis converse. J. Parasitol. 25, 137–139 (1939).
5
J. G. van Oosterwijk, S. Okay. Wikel, Resistance to ticks and the toddle to anti-tick and transmission blockading vaccines. Vaccines (Basel) 9, 725 (2021).
6
P. Willadsen, Antigen cocktails: Safe speculation or unsubstantiated hope? Trends Parasitol. 24, 164–167 (2008).
7
C. Ndawula Jr., A. E. Tabor, Cocktail anti-tick vaccines: The unexpected constraints and approaches against enhanced efficacies. Vaccines (Basel) 8, 457 (2020).
8
X. Hou, T. Zaks, R. Langer, Y. Dong, Lipid nanoparticles for mRNA delivery. Nat. Rev. Mater. , 1–17 (2021).
9
G. Stanek, G. P. Wormser, J. Gray, F. Strle, Lyme borreliosis. Lancet 379, 461–473 (2012).
10
H. D. Kamp, Okay. A. Swanson, R. R. Wei, P. Okay. Dhal, R. Dharanipragada, A. Kern, B. Sharma, R. Sima, O. Hajdusek, L. T. Hu, C. J. Wei, G. J. Nabel, Originate of a broadly reactive Lyme disease vaccine. NPJ Vaccines 5, 33 (2020).
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Science Translational Medication
Volume 13 | Self-discipline 620
November 2021
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Copyright © 2021 The Authors, some rights reserved; irregular licensee American Association for the Advancement of Science. No relate to customary U.S. Government Works.
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Got: 13 September 2021
Permitted: 22 October 2021
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Acknowledgments
We thank P. Šnebergerová for the graphical invent of the figure.
Funding: This work changed into as soon as supported by grant no. 21-08826S from Czech Science Foundation (to P.Okay.), grant no. NU20-05-00396 from Ministry of Health of the Czech Republic (to R.Š.), and Centre for Analysis of Pathogenicity and Virulence of Parasites (no. CZ.02.1.01/0.0/0.0/16_019/0000759) funded by the European Regional Pattern Fund (ERDF) and Ministry of Education, Childhood and Sport (MEYS) (to P.Okay., R.Š., and J.P.).
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Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.
Radek Šíma
Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.
Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.
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